Where to Stay in St. Louis, Missouri: The Best Hotels & Areas

With a rich history, vibrant cultural venues, and diverse architecture, St. Louis, Missouri, offers the perfect Midwest experience. From its bustling downtown to its historic neighborhoods outside the city center, each area of the Gateway City has its own distinct flavor. And with all the great options, deciding where to stay in St. Louis, MO, can be a tough decision.

The city’s downtown areas place you at the center of the excitement and are home to many of the best hotels in St. Louis. Quieter districts like Midtown are full of hidden cultural gems, while neighborhoods like Lafayette Square and Central West End offer a more serene side of the city, with unique shopping, pretty streets, and green spaces,

Not sure where to base yourself? Find your perfect accommodation with this useful guide to the best places to stay in St Louis, MO, including the top areas, neighborhoods, and hotels!

Best places to stay in St. Louis, MO

St. Louis is well-serviced by Metrolink. Wherever you stay in the city, you’ll find it easy to get to all the top attractions. Each area and neighborhood has a great culinary and nightlife scene, so your evenings will always be well catered for. But for convenience and to maximize your time in the city, pick an area that best fits all your travel plans.

If it’s your first time in the city, Downtown St. Louis offers a vibrant atmosphere with excellent accommodation options close to the top tourist sites.

St. Louis, MO

Drawn to St. Louis for its innovative architecture? Stay in Downtown West to explore its historic homes and innovative renovations. Creatives will prefer Midtown for its thriving arts scene.

Or, for a quieter break and high-end activities, Central West End and Lafayette Square offer a laid-back charm and easy access to the rest of the city.

The best areas to stay in St. Louis, MO, are:

Downtown St. Louis

The ideal area to stay in St. Louis for first-time visitors

Want to be in the heart of the action?  Stay in Downtown St. Louis. The city center neighborhood has it all: history, culture, a vibrant arts scene, and fantastic nightlife.

The downtown area starts at the spectacular Gateway Arch. The world’s tallest archway swoops over the city, seamlessly intertwining the old and new architecture. Some of the buildings in this area have been standing since the city’s founding in 1764.

Downtown St. Louis, MO

Downtown is home to some of the top attractions in St. Louis. It’s also a very walkable area, so you can tick off many of the top points of interest in one day.

If you find time, catch a basement game at the Busch Stadium. Watch the Cardinals play with the stunning Downtown St. Louis skyline as your backdrop. Spend endless hours strolling Washington Avenue, a home for unique art, serene parks, and a fun selection of bars.

In Downtown, you’ll find many of the top St. Louis hotels. As it’s the central-most area of the city, you should expect to pay higher prices for lodgings here.

Courtyard St. Louis Downtown

Courtyard St. Louis Downtown/Convention Center

This cozy hotel is the perfect sanctuary after a day of hustle and bustle. Staying in the heart of the city, you’re always a short walk away from Busch Stadium and the City Museum. In this renovated 1929 building, traditional wood paneling gives the modern and convenient facilities a warm atmosphere.

Drury Plaza St. Louis at the Arch

Drury Plaza St. Louis at the Arch

Just around the corner from Gateway Arch, this grand hotel has maintained many of its period features. Dine in the hall alongside marble and chandeliers, or sip a coffee on the modern terrace while you overlook iconic views of Downtown St. Louis. Relax in the evening in the pool and whirlpools, or grab a free meal at the 5.30 kickback event.

Live! by Loews - St. Louis

Live! by Loews – St. Louis

The sleek Live! By Loews hotel offers a laid-back experience at the heart of Downtown. With views of the neighboring Busch Stadium, you can laze on the terrace while you plan your days of adventure. The stunning whisky room and open-air kitchen will provide plenty of ways to spend your evenings.

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

This sophisticated hotel seamlessly blends the old and the new. Art Deco elements and luxurious finishings will leave you feeling like royalty. With such gorgeous surroundings, you’ll have all your vacation photos before you step foot outside the hotel. Savor clever twists on authentic St. Louis dishes or sip on cocktails on the elegant rooftop bar.

Four Seasons St. Louis

Four Seasons St. Louis

Perched on the banks of the Mississippi River, the Four Seasons St. Louis offers a resort experience at the center of the city. Practice your golf swing at the Top Swing Suite, swim in the pool on the sky terrace, or experience total bliss in the on-site spa. Modern rooms with floor-to-ceiling windows provide ultimate comfort.

Downtown West

Top-rated neighborhood to stay in St Louis for architecture buffs

As the name suggests, Downtown West is the western area of Downtown St. Louis. It’s home to some of St. Louis’ most interesting sights. The eclectic blend of architecture here combines multiple eras and cool modern renovations.

The City Museum is no ordinary museum. It has architectural delights and upcycled objects to entertain all ages. Spend your afternoon getting lost in kooky caves, treehouses, and tunnels.

St. Louis City Hall, MO

Union Station opened in 1894, as one of the largest train stations in the world. It’s now a converted host to fun restaurants and recreational activities.

Also on offer is the St. Louis City Hall. The French Renaissance building is an impressive stop on your walk-through Downtown West. Head inside for grand marble staircases and an impressive ceiling.

Downtown West St. Louis is also known for its Washington Avenue Historic District. Once a hub of garment production, the former warehouses have been upgraded into trendy homes, coffee shops, and restaurants.

Tru By Hilton St Louis Downtown Mo

Tru By Hilton St Louis Downtown

The Tru by Hilton is surrounded by some of the most beautiful buildings in the city, including the pretty neighboring Catholic church. The freshly renovated building provides large and modern spaces for you to relax and a free breakfast to fuel your days. Their friendly lobby space features a game zone, work area, and 24/7 convenience store.

Fairfield Inn and Suites by Marriott St Louis Downtown

Fairfield Inn and Suites by Marriott St Louis Downtown

This modern hotel offers lots of elegant places for you to unwind. Curl up by the fireplace on the sleek outdoor patio, or keep up your workout routine in the on-site gym. The convenient location gives you quick access to the St. Louis Aquarium and Busch Stadium.

Drury Inn St. Louis Union Station

Drury Inn St. Louis Union Station

Stay in history at this renovated 1907 St. Louis Railroad YMCA building. Original features like wood paneling and marble stairs are combined with comfortable modern fixtures, giving the place a warm and welcoming feeling. Snuggle up in your room, complete with its own fireplace.

The Last Hotel St Louis

The Last Hotel

This boutique hotel is dripping with Art Deco elegance. The 1909 building was originally the home of the International Shoe Company. Despite expert renovations, its heritage has been preserved with beautiful luxury details. Get your pasta fix at the Italian-inspired steakhouse and sip on cocktails in the pool at the exclusive rooftop bar.


The perfect district to stay in St Louis for art lovers

The pretty Midtown area offers plenty of variety and culture. It’s the home of major St. Louis attractions like the St Louis Art Museum and the St. Louis Science Center. If you’re passionate about the arts, Midtown will give you endless joy. Catch a show at The Muny, the largest outdoor theatre in the US. Or, take a peek into the life of a famous composer at the Scott Joplin House.

St. Louis Art Museum

The apartment of Tennessee Williams is in Central West End, and it’s easy to see where he got his inspiration. The delightful district is abundant with pretty cafes, galleries, and stately homes. Explore the Cathedral Basilica of Saint Louis, which has the largest collection of mosaic art in the world.

St. Louis University is based in the Grand Center Arts District, the creative soul of the city. The unparalleled selection of galleries, theatres, and cultural events is sure to have you leave St. Louis with new inspiration.

Residence Inn by Marriott St. Louis Downtown

Residence Inn by Marriott St. Louis Downtown

If you’re seeking a stay with a little more privacy, Residence Inn has suites and apartments with your own living space and kitchen. You’ll also have access to the hotel bar, gym, and outdoor patio. With a short distance to the Peabody Theatre and St Louis Zoo, it’s a simple and pleasant place to base for your trip.

Angad Arts Hotel St Louis

Angad Arts Hotel

The Angad Arts Hotel fits right in at its Grand Center Arts District location. The eclectic space is a treasure cave of art exhibitions and creative events. Pick a room designed to create the mood you want to feel on your trip to St. Louis. Start your day with innovative breakfasts like pork belly benedict. Finish with unusual cocktails at the art bar.

Element St. Louis Midtown

Element St. Louis Midtown

If you don’t want to disrupt your health and mindfulness routine while you travel, this hotel offers the ideal solution. The sustainable hotel provides a healthy breakfast, serene rooms, and an onsite pool and fitness center. Open, breezy spaces and your own kitchen help you to maintain the perfect balance while you travel.

Central West End

A great neighborhood to stay for relaxation

The eclectic Central West End offers something for every type of traveler. From stained glass window painting to creating your own body oil, there are endless charming activities to try.

The Central West End is very walkable, covering just under a mile of the city. Antique stores and streetside patios give the area an old-world European feel. You’ll wander between attractions through green spaces and streets sheltered with old-growth trees.

Forest Park

The area borders Forest Park, one of the most beautiful urban parks in the world. With 1,300 acres of forests and lakes, Forest Park is the perfect escape without leaving the city.

If you want more connection with nature, head to St. Louis Zoo, one of the most popular Saint Louis day trips. The free attraction is a leader in conservation and research. Meet polar bears, hippos, and penguins in exhibits that mimic their natural environments.

Or visit the prestigious Washington University. As the university was founded back in 1863, you’ll be able to stroll some of the historic campus grounds, keeping your eye out for historic gems.

AC Hotel by Marriott St Louis Central West End

AC Hotel by Marriott St Louis Central West End

You’ll leave this minimalist but stylish hotel feeling calm and rested. The sophisticated design focuses on minimizing waste and clutter. Start your day with a healthy breakfast and wrap it up with cocktails and tapas in the beautiful drinks lounge. With Central West End’s top sights on your doorstep, you can enjoy a rejuvenating city break.

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

This casual hotel provides everything you need for a seamless St Louis vacation. It’s at the heart of Central West End and three blocks from a Metrolink so it’s the perfect base for exploring the city. Functional rooms offer comfort and convenience in a modern style. Start your stay with a tasty complimentary cookie.

Home2 Suites St. Louis

Home2 Suites St. Louis / Forest Park

If you’re seeking space and privacy, Home2 Suites St. Louis is the ideal hotel for you. Spacious apartments with TV, lounge area, and kitchenette have a colorful and homey feel. You don’t have to sacrifice hotel facilities. There’s a pool, fitness center, and room service at your fingertips.

The Royal Sonesta Chase Park Plaza

The Royal Sonesta Chase Park Plaza

This stunning Art Deco building has stood since 1922. With Hollywood glamor at every turn, a night here offers pure luxury. Take a dip in the outdoor swimming pool lined with grand columns and palm trees, or curl up by an elegant Art Deco fireplace.

Lafayette Square

The best area for luxury travelers

Lafayette Square is the oldest area of St. Louis. This colorful neighborhood is known for its pretty historic homes. Stunning Victorian mansions in pastel shades will have you feeling like you’re walking in your own period drama. Known as the “painted ladies,” these houses have become an iconic part of the city.

Lafayette Park St Louis

The homes surround the 30-acre Lafayette Park. This urban oasis is dripping with Victorian charm. Original ironwork and fountains intertwine with vibrant flowers and waterfalls. If you’re visiting in summer, one of the best times of the year to visit St. Louis, stroll around the romantic lakeside or watch a baseball game on the vintage-style field.

Today, Lafayette Square is a laid-back and trendy part of the city. Indulge in gourmet dining and wine tastings from some of the top sommeliers in the city. Expert wine bars and breweries, sophisticated bistros, and quirky coffee shops will have you loving the St. Louis lifestyle.

Pick up unique and personalized gifts from the art studios and boutiques or while away an afternoon in one of the spas.

There’s a limited selection of accommodations in the area, with vacation rentals and bed & breakfasts rather than hotels comprising the bulk of the lodgings.

Lehmann House Bed & Breakfast St. Louis

Lehmann House Bed & Breakfast

Stay in an elegant 1800s mansion for a true Victorian experience. The rooms are renovated to perfection, with many of their original details preserved. Listen to the sound of the baby grand piano in the parlor or curl up with a book in the impressive library.

Luxe LF Square 1BR

Luxe LF Square 1BR

Live like a local in a large, stylish apartment in Lafayette Square. Exposed brick and dark finishings make this a super cool place to sleep during your trip. It’s in a central location for all the area’s attractions and the pretty rooftop terrace gives you views across the city.

Revived LF Square 1BR

Revived LF Square 1BR with Rooftop by Zencity

Another stylish apartment in the heart of the Lafayette Square neighborhood, this one-bedroom property shines with contemporary design and extra amenities like a fitness center, terrace, and free WiFi. 


Ryan O'Rourke is a seasoned traveler and the founder & editor of Treksplorer, a fiercely independent guide to mid-range luxury travel for busy people. With over 20 years of extensive travel experience, Ryan has journeyed through over 50 countries, uncovering hidden gems and sharing firsthand, unsponsored insights on what to see & do and where to eat, drink & stay. Backed by his travel experience and in-depth research, Ryan’s travel advice and writing has been featured in publications like the Huffington Post and Matador Network. You can connect with Ryan on Twitter/X at @rtorourke.

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